Containment, pressure cascades, validation

    Commissioning software for laboratories where a pressure cascade a few pascals out fails the whole room.

    Laboratories and research facilities depend on fume cupboards, containment and pressure cascades performing to a tolerance most buildings never need to consider, then proving it through a validation process before a single sample is handled. Deskely tracks each room, containment zone and piece of critical equipment against its own performance criteria, with validation evidence built in as it is generated.

    Unit
    Room, zone, containment tier
    Tolerance
    Pressure cascade, ACH
    Process
    Commissioning then validation
    Gate
    Qualified for occupancy
    RESEARCH BUILDING — BSL-3 SUITECONTAINMENT RECORD SET · REV DRESEARCH SUITE — BSL2LAB-FCU-06PRESSURE CASCADEP1 −10 PaP2 −25 PaP3 −40 PaCascade unverifiedTAG REGISTERAHU-04Containment suite supply …Records signedFAP-B2HEPA filter access panel,…In testBMS-CTRL-07Pressure cascade controll…PreservationSMK-EX-01Containment exhaust fanPunch open38 unitsunder one system hierarchy

    The problem

    Commissioning proves the system works; validation has to prove it separately, in writing.

    Fume cupboards, biosafety cabinets, containment suites and clean spaces depend on precise air change rates, pressure cascades and face velocities, all interacting with each other across adjoining rooms.

    A validation process then repeats much of the testing under its own protocol, and any gap between the commissioning record and the validation requirement becomes rework at the worst possible time.

    Deskely defines room-level performance criteria once and structures both commissioning and validation evidence against the same room and equipment tags, so the two processes reference one dataset instead of two.

    COMMISSIONED IS NOT THE SAME AS VALIDATEDContainment lab, pressure cascadeA room can pass commissioning and still fail validation if the two records disagreeAnteroom+10 PaLab−15 PaContainment core−30 PaCascade direction proven by commissioning, room by roomVALIDATION PROTOCOL DISAGREES WITH THE Cx RECORDIQ/OQ for containment core references a setpoint the commissioning report never recorded1 roomcannot be qualified until the two records reconcile1 trailcommissioning and validation evidence held against the same roomDeskely keeps commissioning and validation evidence on the same room record, so gaps surface immediately.

    Setting up the register

    Rooms, containment zones and critical equipment carry their own performance criteria.

    Laboratories, containment suites, cleanrooms, fume cupboards, biosafety cabinets and specialist gas and vacuum services are tagged with the specific air change rate, pressure differential and face velocity criteria they must meet.

    Adjoining rooms and their pressure relationships are modelled explicitly, since a cascade failure in one room is frequently caused by a change in an adjacent one.

    Room data sheets, HVAC schedules and equipment specifications are parsed into that structure, so the pass/fail criteria used in testing come from the approved design rather than a technician's memory.

    1 · SOURCE DOCUMENTSContainment strategy rev…14 zonesFume cupboard and BSC sc…38 unitsPressure cascade point s…2 240 pointsHEPA filtration schedule22 filtersPARSE + MATCHtag · description · drawing ref2 · ONE TAG REGISTERAHU-04Containment suite supply …BSL-3 SUITEFAP-B2HEPA filter access panel,…BSL-3 SUITEBMS-CTRL-07Pressure cascade controll…CONTROLSSMK-EX-01Containment exhaust fanEXHAUSTTWO DOCUMENTS DISAGREEContainment strat…Pressure cascade controllerFume cupboard and…Abbreviated descriptionEngineer picks the sourcedecision loggedWeeks of transcription become a draft an engineer reviews.

    Execution

    Pre-functional checks, functional testing and validation protocols share one evidence trail.

    Pre-functional checks confirm installation of ductwork, dampers, controls and containment devices before functional testing measures air change rates, face velocities and pressure cascades against the room's defined criteria.

    Fume cupboard and biosafety cabinet performance is tested and recorded against the specific unit, with results held against both the equipment tag and the room it serves.

    Where a validation protocol repeats a test, it is executed against the same room and equipment record, so commissioning results and validation results are traceable to the same underlying data rather than duplicated by hand.

    IQ / OQ / PQ AGAINST COMMISSIONINGContainment lab, room qualificationCommissioning — pre-functional checksSigned offIQ — installation qualificationSigned offOQ — operational qualificationIn progressPQ — performance qualificationAwaiting predecessorRoom released for research useAwaiting predecessor2 of 5gates cleared toward room releaseCommissioning and validation evidence sit in the same ladder, so no gate is skipped.

    Handover and qualification

    A room is qualified for occupancy when both commissioning and validation agree.

    Room qualification certificates are issued from the combined commissioning and validation record set, with any deviation logged as a punch item against the room or the piece of equipment causing it.

    The O&M and validation pack hands over containment performance history, alarm setpoints and calibration records together, which is what a research organisation's quality function will ask for at audit.

    Ongoing periodic verification, once occupancy begins, references the same baseline data rather than starting a fresh testing programme from scratch.

    Lab 3 — accreditation ladderAccreditation issues only from signed validation evidenceICInstallation completeRecords signed 15 OctHEPA filter installation records22 / 22 signedContainment fabric integritycompleteVTValidation testIn test — face velocity survey bookedPressure cascade provenconfirmedHEPA filter integritypassedACAccreditationPunch open — 7 itemsBlocking punch7 openBiosafety officer sign-offnot witnessed

    How it runs

    From shell space to a qualified laboratory.

    Laboratory fit-outs are unforgiving of any gap between commissioning and validation, which is precisely the gap a shared register closes.

    1. 01

      Define room performance criteria

      Air change rate, pressure cascade and face velocity criteria tagged against every room and adjoining room from the approved design.

    2. 02

      Register containment equipment

      Fume cupboards, biosafety cabinets and containment devices tagged with their room and their performance specification.

    3. 03

      Run functional and validation testing

      Air change, pressure cascade and containment device performance tested and recorded against the same room and equipment tags used by validation.

    4. 04

      Qualify room by room

      Room qualification certificates issued from the combined commissioning and validation record set, with deviations tracked as punch.

    FAQ

    Questions about Laboratories and research facilities scopes.

    Ready to digitize
    commissioning and
    handover?

    We use cookies to improve your experience.
    You can opt out of certain cookies.
    Find out more in our privacy policy.